The Sound of Evolution
Pyrazinamide
吡嗪醯胺
Mechanism of action:
Pyrazinamide 是一種吡𠯤甲醯胺類（pyrazinecarboxamide）衍生物。Pyrazinamide 進入結核分枝桿菌後，被細菌特有的吡𠯤醯胺酶/菸鹼醯胺酶（pyrazinamidase/nicotinamidase）水解為 pyrazinoic acid。Pyrazinoic acid 在細菌內累積會干擾膜電位（membrane potential），抑制能量生成與質子動力（proton motive force），使細菌在低代謝狀態下仍無法存活。
Reference(s):
1. Yee D et al. (2003). Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis. Am J Respir Crit Care Med.
2. Boshoff HI et al. (2002). Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I. J Bacteriol.
3. Zimhony O et al. (2007). Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli. Antimicrob Agents Chemother.