top of page
The Sound of Evolution
Pyrimethamine
乙胺嘧啶
Mechanism of action:
Pyrimethamine 是一種二氨基嘧啶類（diaminopyrimidine）衍生物。Pyrimethamine 會高親和力結合並抑制原蟲，如弓形蟲（Toxoplasma gondii）、瘧原蟲（Plasmodium spp.）的二氫葉酸還原酶（dihydrofolate reductase），阻斷二氫葉酸（dihydrofolic acid）轉換為四氫葉酸（tetrahydrofolic acid），使 DNA 與 RNA 合成受阻。
Reference(s):
1. Gatton ML et al. (2004). Evolution of resistance to sulfadoxine-pyrimethamine in Plasmodium falciparum. Antimicrob Agents Chemother.
2. Sirichaiwat C et al. (2004). Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum. J Med Chem.
bottom of page