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The Sound of Evolution
Quinapril
喹那普利
Mechanism of action:
Quinapril 是一種血管張力素轉化酶抑制劑（angiotensin-converting enzyme inhibitor）。Quinapril 在體內經肝臟水解後會轉化為其活性形式 quinaprilat，會抑制血管張力素 I 轉化酶（angiotensin-converting enzyme）的功能。血管張力素 I 轉化酶負責將血管張力素 I（angiotensin I）轉化為血管張力素 II（angiotensin II），促進血管收縮提升血壓。當 quinaprilat 抑制血管張力素 I 轉化酶後，血管張力素 II 的量減少，使血管收縮訊號下降並降低血流動力學負荷。
Reference(s):
1. Kieback AG et al. (2009). Quinaprilat: a review of its pharmacokinetics, pharmacodynamics, toxicological data and clinical application. Expert Opin Drug Metab Toxicol.
2. Tsikouris JP et al. (2004). Questioning a class effect: does ACE inhibitor tissue penetration influence the degree of fibrinolytic balance alteration following an acute myocardial infarction? J Clin Pharmacol.
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