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Quinupristin

奎奴普丁

Mechanism of action:

Quinupristin 是一種鏈陽菌素類（streptogramin B）抗生素。Quinupristin 專一性結合於細菌的 50S 核糖體亞基的肽鏈延伸區域，阻斷肽鏈延長過程中的轉肽作用（transpeptidation），抑制蛋白質延長與釋放未完成肽鏈，使細菌生長受阻。

​Reference(s):

1. Allington DR et al. (2001). Quinupristin/dalfopristin: a therapeutic review. Clin Ther. 


2. Lamb HM et al. (1999). Quinupristin/dalfopristin: a review of its use in the management of serious gram-positive infections. Drugs. 


3. Manzella JP et al. (2001). Quinupristin-dalfopristin: a new antibiotic for severe gram-positive infections. Am Fam Physician.

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