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Raltegravir

拉替拉韋

Mechanism of action:

Raltegravir 是人類免疫缺乏病毒（HIV）整合酶抑制劑（integrase strand transfer inhibitor）。HIV 病毒在反轉錄後會產生雙股 DNA，整合酶會將該 DNA 插入宿主染色體中，病毒才能進行後續轉錄與複製。Raltegravir 會選擇性結合於整合酶的活性位點，阻斷病毒 DNA 與宿主 DNA 之間的轉移反應。

​Reference(s):

1. Nachman S et al. (2014). Pharmacokinetics, safety, and 48-week efficacy of oral raltegravir in HIV-1-infected children aged 2 through 18 years. Clin Infect Dis. 


2. Barau C et al. (2013). Characterization of binding of raltegravir to plasma proteins. Antimicrob Agents Chemother. 


3. Arora R et al. (2013). Raltegravir flexibility and its impact on recognition by the HIV-1 IN targets. J Mol Recognit.

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