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The Sound of Evolution
Ramipril
雷米普利
Mechanism of action:
Ramipril 是一種血管張力素轉化酶抑制劑（angiotensin-converting enzyme inhibitor）。Ramipril 在體內經肝臟水解後會轉化為其活性形式 ramiprilat，會抑制血管張力素 I 轉化酶（angiotensin-converting enzyme）的功能。血管張力素 I 轉化酶負責將血管張力素 I（angiotensin I）轉化為血管張力素 II（angiotensin II），促進血管收縮提升血壓。當 ramiprilat 抑制血管張力素 I 轉化酶後，血管張力素 II 的量減少，使血管收縮訊號下降並降低血流動力學負荷。
Reference(s):
1. Cacciapuoti F et al. (1998). Prevention of left ventricular hypertrophy by ACE-inhibitor, ramipril in comparison with calcium-channel antagonist, felodipine. Int J Cardiol.
2. Kleinert S et al. (1999). HOPE for cardiovascular disease prevention with ACE-inhibitor ramipril. Lancet.
3. Douros A et al. (2013). Ramipril-induced liver injury: case report and review of the literature. Am J Hypertens.
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