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Ranitidine

雷尼替丁

Mechanism of action:

Ranitidine 是一種組織胺 H₂ 受體拮抗劑（H₂ receptor antagonist）。Ranitidine 會與胃壁細胞基底側膜（basolateral membrane）上的 H₂ 受體結合，阻斷組織胺（histamine）對該受體的活化作用，而抑制 Gs-腺苷酸環化酶（adenylyl cyclase）-cAMP 路徑，減少氫鉀幫浦（H⁺/K⁺-ATPase）活性，使胃酸分泌量降低。

​Reference(s):

1. Mauran A et al. (2016). Mania associated with ranitidine: a case report and review of literature. Fundam Clin Pharmacol. 


2. Grant SM et al. (1989). Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases. Drugs.

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