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Retapamulin

瑞他莫林

Mechanism of action:

Retapamulin 是一種截短側耳素類（pleuromutilin）抗生素。Retapamulin 會結合在細菌的 50S 核糖體亞基的肽轉移中心（peptidyl transferase center），該結合位點與巨環內酯類（macrolide）、林克醯胺類（lincosamide）、鏈陽菌素類（streptogramin）的抗生素不同。Retapamulin 能干擾 tRNA 在 A 位點與 P 位點間的正確定位，而抑制肽鍵形成與早期蛋白質延長，導致細菌蛋白質合成受阻。

​Reference(s):

1. Jones RN et al. (2006). Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci. Antimicrob Agents Chemother. 


2. Yang LP et al. (2008). Retapamulin: a review of its use in the management of impetigo and other uncomplicated superficial skin infections. Drugs. 


3. Novak R et al. (2010). The pleuromutilin antibiotics: a new class for human use. Curr Opin Investig Drugs.

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