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The Sound of Evolution
Ropinirole
羅匹尼羅
Mechanism of action:
Ropinirole 是一種多巴胺受體促效劑（dopamine receptor agonist）。Ropinirole 對 D₂ 和 D₃ 受體的親和力較高，活化受體後，透過 Gi/o 蛋白偶聯抑制腺苷酸環化酶（adenylyl cyclase），使 cAMP 下降，降低抑制性輸出核（如內側蒼白球，globus pallidus internus）的過度活化。
Reference(s):
1. Matheson AJ et al. (2000). Ropinirole: a review of its use in the management of Parkinson's disease. Drugs.
2. Nashatizadeh MM et al. (2009). A review of ropinirole prolonged release in Parkinson's disease. Clin Interv Aging.
3. Kushida CA et al. (2006). Ropinirole for the treatment of restless legs syndrome. Neuropsychiatr Dis Treat.
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