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Rotigotine

羅替戈汀

Mechanism of action:

Rotigotine 是一種多巴胺受體促效劑（dopamine receptor agonist）。Rotigotine 能作用於 D₁、D₂、D₃ 受體，但對 D₃ 受體親和力最高，對 D₁ 受體則最低。當受體受 rotigotine 活化後，透過 Gi/o 蛋白偶聯抑制腺苷酸環化酶（adenylyl cyclase），使 cAMP 下降，調節基底核（basal ganglia）運動迴路。

​Reference(s):

1. Giladi N et al. (2007). Rotigotine transdermal patch in early Parkinson's disease: a randomized, double-blind, controlled study versus placebo and ropinirole. Mov Disord. 


2. Chen JJ et al. (2009). Transdermal rotigotine: a clinically innovative dopamine-receptor agonist for the management of Parkinson's disease. Pharmacotherapy. 


3. Perez-Lloret S et al. (2013). Rotigotine transdermal patch for the treatment of Parkinson's Disease. Fundam Clin Pharmacol.

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