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Sacubitril

沙庫巴曲

Mechanism of action:

Sacubitril 是一種腦啡肽酶抑制劑（neprilysin inhibitor）。Sacubitril 為前軀藥，在體內需代謝成具有活性的 sacubitrilat。腦啡肽酶（neprilysin）負責分解多種具保護作用的血管活性胜肽，包括心房利尿鈉肽（atrial natriuretic peptide）、腦利鈉利尿胜肽（brain natriuretic peptide）等。當腦啡肽酶受到 sacubitrilat 抑制後，血管活性胜肽分解減少，可產生血管擴張、利鈉與利尿作用、抑制心肌纖維化與心室重塑等。

​Reference(s):

1. Gu J et al. (2010). Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi). J Clin Pharmacol. 


2. Mills J et al. (2015). The Role of Neprilysin Inhibitors in Cardiovascular Disease. Curr Heart Fail Rep. 


3. King JB et al. (2015). Neprilysin Inhibition in Heart Failure with Reduced Ejection Fraction: A Clinical Review. Pharmacotherapy.

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