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Scopolamine

東莨菪鹼

Mechanism of action:

Scopolamine 是一種毒蕈鹼型乙醯膽鹼受體拮抗劑（muscarinic acetylcholine receptor antagonist），屬於莨菪烷類生物鹼（tropane alkaloid）衍生物。Scopolamine 可與 M₁-M₅ 的毒蕈鹼型受體結合，尤其對中樞神經系統中的 M₁ 受體影響顯著，因此抑制乙醯膽鹼（acetylcholine）的作用，降低前庭刺激傳入嘔吐中樞的強度。

​Reference(s):

1. Putcha L et al. (1989). Pharmacokinetics and oral bioavailability of scopolamine in normal subjects. Pharm Res. 


2. Kruse AC et al. (2014). Muscarinic acetylcholine receptors: novel opportunities for drug development. Nat Rev Drug Discov. 


3. Moran SP et al. (2019). Targeting Muscarinic Acetylcholine Receptors for the Treatment of Psychiatric and Neurological Disorders. Trends Pharmacol Sci.

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