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Semaglutide

司美格魯肽

Mechanism of action:

Semaglutide 是一種類升糖素胜肽-1 受體促效劑（glucagon-like peptide-1 receptor agonist）。Semaglutide 藉由與胰島 β 細胞上的 GLP-1 受體結合，促進葡萄糖依賴性的胰島素分泌，同時抑制升糖素釋放、延緩胃排空並降低食慾，降低餐後與空腹血糖相關負荷。

​Reference(s):

1. Gotfredsen CF et al. (2014). The human GLP-1 analogs liraglutide and semaglutide: absence of histopathological effects on the pancreas in nonhuman primates. Diabetes. 


2. Blundell J et al. (2017). Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity. Diabetes Obes Metab. 


3. Lee YS et al. (2014). Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells. Metabolism.

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