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The Sound of Evolution
Simvastatin
辛伐他汀
Mechanism of action:
Simvastatin 是一種 HMG-CoA 還原酶抑制劑（HMG-CoA reductase inhibitor）。Simvastatin 會與 HMG-CoA 還原酶結合，抑制其將 HMG-CoA 轉化為甲羥戊酸（mevalonate），降低肝臟內膽固醇生成，使肝細胞內膽固醇濃度下降，之後導致上調肝細胞的 LDL 受體表達，增強血液的低密度脂蛋白膽固醇（LDL-C）的攝取與分解。最終血漿中 LDL-C、總膽固醇、極低密度脂蛋白（VLDL）以及三酸甘油脂可下降，同時高密度脂蛋白膽固醇（HDL-C）可能輕微上升。
Reference(s):
1. Wolozin B et al. (2007). Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med.
2. Moghadasian MH et al. (1999). Clinical pharmacology of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Life Sci.
3. Anderson TJ et al. (2016). 2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult. Can J Cardiol.
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