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The Sound of Evolution
Sodium fluoride
氟化鈉
Mechanism of action:
Sodium fluoride 在口腔中會釋放氟離子（F⁻），氟離子可與牙齒琺瑯質中的羥磷灰石（hydroxyapatite）反應，形成氟磷灰石（fluorapatite）。氟磷灰石溶解度較低，對酸的抵抗力明顯高於羥磷灰石，使牙齒對細菌產酸的侵蝕更具耐受性。此外，氟離子可進入口腔細菌（如轉糖鏈球菌，Streptococcus mutans）細胞內，在酸性環境下形成氫氟酸，進而抑制細菌的烯醇化酶（enolase），干擾糖解作用（glycolysis），降低乳酸生成，減少牙菌斑產酸能力，降低蛀牙風險。
Reference(s):
1. Kanduti D et al. (2016). FLUORIDE: A REVIEW OF USE AND EFFECTS ON HEALTH. Mater Sociomed.
2. Peckham S et al. (2014). Water fluoridation: a critical review of the physiological effects of ingested fluoride as a public health intervention. ScientificWorldJournal.
3. Ekstrand J et al. (1990). Fluoride pharmacokinetics: its implications in the fluoride treatment of osteoporosis. J Bone Miner Res.
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