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Succinylcholine

琥珀膽鹼

Mechanism of action:

Succinylcholine 是一種去極化型神經肌肉阻斷劑（depolarizing neuromuscular blocking agent），屬於乙醯膽鹼類似物（acetylcholine analog）。Succinylcholine 能與運動終板（motor end-plate）上的菸鹼型乙醯膽鹼受體（nicotinic acetylcholine receptor）結合，模擬乙醯膽鹼（acetylcholine）的作用，造成去極化（depolarization），但 succinylcholine 不會被突觸間隙的乙醯膽鹼酯酶（acetylcholinesterase）快速分解，使運動終板長時間維持在去極化狀態，形成鬆弛性麻痺（flaccid paralysis）。

​Reference(s):

1. Jonsson M et al. (2006). Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine. Anesthesiology. 


2. Alvarellos ML et al. (2015). PharmGKB summary: succinylcholine pathway, pharmacokinetics/pharmacodynamics. Pharmacogenet Genomics. 


3. Kato M et al. (1999). Comparison between in vivo and in vitro pharmacokinetics of succinylcholine in humans. J Anesth.

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