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Sulfadiazine

磺胺嘧啶

Mechanism of action:

Sulfadiazine 是一種磺胺類抗生素（sulfonamide antibiotic）。Sulfadiazine 在結構上類似對胺基苯甲酸（PABA），而對胺基苯甲酸是細菌合成葉酸所必需的前驅物。Sulfadiazine 與對胺基苯甲酸競爭結合二氫蝶酸合成酶（dihydropteroate synthase），阻斷二氫葉酸（dihydrofolic acid）的生成，最後導致細菌的核酸合成受阻。

​Reference(s):

1. de Araujo MV et al. (2008). Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Bioorg Med Chem. 


2. Iliades P et al. (2005). Mutations in the Pneumocystis jirovecii DHPS gene confer cross-resistance to sulfa drugs. Antimicrob Agents Chemother. 


3. Prabhu V et al. (1997). Arabidopsis dihydropteroate synthase: general properties and inhibition by reaction product and sulfonamides. Phytochemistry.

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