The Sound of Evolution
Sumatriptan
舒馬曲普坦
Mechanism of action:
Sumatriptan 是一種血清素 5-HT₁B/5-HT₁D 受體促效劑（selective 5-HT₁B/5-HT₁D receptor agonist），屬於翠普登類（triptan）。Sumatriptan 的作用集中於顱內三叉神經與週遭血管系統（trigeminovascular system），刺激顱內（特別是硬腦膜）血管平滑肌上的 5-HT₁B 受體，使顱內血管張力上調並引發血管收縮反應；在三叉神經末梢刺激 5-HT₁D 受體，減少抑鈣基因相關胜肽（calcitonin gene-related peptide）、P 物質（substance P）等促發炎與致痛神經胜肽的釋放，減少神經性發炎與疼痛傳導。
Reference(s):
1. Nikai T et al. (2008). Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan. Pain.
2. Ferrari MD et al. (1992). Clinical effects and mechanism of action of sumatriptan in migraine. Clin Neurol Neurosurg.
3. Duquesnoy C et al. (1998). Comparative clinical pharmacokinetics of single doses of sumatriptan following subcutaneous, oral, rectal and intranasal administration. Eur J Pharm Sci.