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The Sound of Evolution
Tadalafil
他達拉非
Mechanism of action:
Tadalafil 是一種第 5 型磷酸二酯酶抑制劑（phosphodiesterase type 5 inhibitor）。第 5 型磷酸二酯酶（phosphodiesterase type 5）是負責分解環磷酸鳥苷（cGMP）的酵素，在陰莖海綿體與肺血管平滑肌中特別豐富。Tadalafil 可選擇性抑制此酵素，減少 cGMP 的降解。cGMP 會活化蛋白激酶 G（protein kinase G），使細胞內鈣離子濃度下降，海綿體與血管平滑肌放鬆，血流量增加。
Reference(s):
1. Forgue ST et al. (2006). Tadalafil pharmacokinetics in healthy subjects. Br J Clin Pharmacol.
2. Andersson KE et al. (2018). PDE5 inhibitors - pharmacology and clinical applications 20 years after sildenafil discovery. Br J Pharmacol.
3. Arif SA et al. (2011). Tadalafil: a long-acting phosphodiesterase-5 inhibitor for the treatment of pulmonary arterial hypertension. Clin Ther.
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