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Tamsulosin

坦索羅辛

Mechanism of action:

Tamsulosin 是一種選擇性 α₁-腎上腺素受體阻斷劑（selective α₁-adrenergic antagonist）。Tamsulosin 主要作用於前列腺與膀胱出口平滑肌的 α₁A 受體（Gq/11 蛋白偶聯受體），抑制正腎上腺素（norepinephrine）引起的平滑肌收縮。

​Reference(s):

1. Dunn CJ et al. (2002). Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms. Drugs Aging. 


2. Matsushima H et al. (1998). Pharmacokinetics and plasma protein binding of tamsulosin hydrochloride in rats, dogs, and humans. Drug Metab Dispos. 


3. Soeishi Y et al. (1996). Absorption, metabolism and excretion of tamsulosin hydrochloride in man. Xenobiotica.

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