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Tenoxicam

替諾昔康

Mechanism of action:

Tenoxicam 是一種昔康類（oxicam）衍生物。Tenoxicam 能抑制環氧化酶（cyclooxygenase），包含 COX-1 與 COX-2，阻止將花生四烯酸（arachidonic acid）轉換為前列腺素（prostaglandin），降低前列腺素介導的發炎訊號、疼痛敏感化與發燒反應。

​Reference(s):

1. Kothekar V et al. (2001). Recognition of cyclooxygenase-2 (COX-2) active site by NSAIDs: a computer modelling study. Indian J Biochem Biophys. 


2. Yamada M et al. (1997). Prostaglandin E2 production dependent upon cyclooxygenase-1 and cyclooxygenase-2 and its contradictory modulation by auranofin in rat peritoneal macrophages. J Pharmacol Exp Ther.

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