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Theobromine

可可鹼

Mechanism of action:

Theobromine 是一種甲基黃嘌呤類（methylxanthine）化合物。Theobromine 對磷酸二酯酶（phosphodiesterase）的抑制能力明顯弱於咖啡因（caffeine）與茶鹼（theophylline），但仍可使細胞內 cAMP、cGMP 濃度輕度上升，進而導致平滑肌放鬆、輕度支氣管擴張、血管舒張等。Theobromine 能輕微拮抗腺苷受體（adenosine receptor）A₁ 與 A₂A 受體，減少腺苷對中樞神經的抑制性影響。

​Reference(s):

1. Usmani OS et al. (2005). Theobromine inhibits sensory nerve activation and cough. FASEB J. 


2. Slattery ML et al. (1993). Smoking, alcohol, coffee, tea, caffeine, and theobromine: risk of prostate cancer in Utah (United States). Cancer Causes Control.

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