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The Sound of Evolution
Thiamylal
硫美妥
Mechanism of action:
Thiamylal 是一種硫代巴比妥酸（thiobarbiturate）衍生物。Thiamylal 會結合於 GABA_A 受體的巴比妥結合位點，增強 GABA 的抑制作用，延長氯離子通道開啟時間，使氯離子內流增加，導致神經元膜電位超極化（hyperpolarization），使神經元更不容易產生動作電位。
Reference(s):
1. Eguchi S et al. (2005). [Effects of propofol and thiamylal on nicorandil induced ATP-sensitive potassium channel activities in cultured rat aortic smooth muscle cells]. Masui.
2. Kawano T et al. (2004). Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology.
3. Tsutsumi Y et al. (2000). Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes. Anesthesiology.
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