top of page
< Back

Thioguanine

硫鳥嘌呤

Mechanism of action:

Thioguanine 是一種硫嘌呤（thiopurine）衍生物。Thioguanine 進入細胞後，由次黃嘌呤-鳥嘌呤磷酸核苷轉移酶（hypoxanthine-guanine phosphoribosyltransferase）轉化為活性代謝物 thioguanine nucleotides。Thioguanine nucleotides 會抑制多個嘌呤合成途徑中的重要酵素，導致 GMP、AMP 生成下降，使快速分裂的腫瘤細胞無法獲得足夠核苷酸。

​Reference(s):

1. Schwartz EL et al. (1983). Induction of leukemia cell differentiation by chemotherapeutic agents. Adv Enzyme Regul. 


2. Riscoe MK et al. (1989). Purine metabolism as a target for leukemia chemotherapy. Blood Rev. 


3. Sahasranaman S et al. (2008). Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol.

bottom of page