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Thiopental

硫噴妥

Mechanism of action:

Thiopental 是一種硫代巴比妥酸（thiobarbiturate）衍生物。Thiopental 會結合於 GABA_A 受體的巴比妥結合位點，增強 GABA 的抑制作用，延長氯離子通道開啟時間，使氯離子內流增加，導致神經元膜電位超極化（hyperpolarization），使神經元更不容易產生動作電位。

​Reference(s):

1. Morgan DJ et al. (1981). Pharmacokinetics and plasma binding of thiopental. II: Studies at cesarean section. Anesthesiology. 


2. Winters WD et al. (1955). Metabolism of thiopental-S35 and thiopental-2-C14 by a rat liver mince and identification of pentobarbital as a major metabolite. J Pharmacol Exp Ther. 


3. Bory C et al. (1986). [Use of thiopental in man. Determination of this drug and its metabolites in plasma and urine by liquid phase chromatography and mass spectrometry]. C R Acad Sci III.

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