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The Sound of Evolution
Thioridazine
硫利達嗪
Mechanism of action:
Thioridazine 屬於多受體拮抗型分子。Thioridazine 會拮抗中腦邊緣通路（mesolimbic pathway）的多巴胺 D₂ 受體，降低多巴胺過度活化造成的陽性症狀；也能拮抗毒蕈鹼型乙醯膽鹼受體（muscarinic acetylcholine receptor），降低 D₂ 阻斷所造成的錐體外症狀（extrapyramidal symptoms，EPS）。
Reference(s):
1. Seeman P et al. (1990). Atypical neuroleptics: role of multiple receptors, endogenous dopamine, and receptor linkage. Acta Psychiatr Scand Suppl.
2. Assie MB et al. (1993). Biphasic displacement of [3H]YM-09151-2 binding in the rat brain by thioridazine, risperidone and clozapine, but not by other antipsychotics. Eur J Pharmacol.
3. Dimpfel W et al. (1992). Different neuroleptics show common dose and time dependent effects in quantitative field potential analysis in freely moving rats. Psychopharmacology (Berl).
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