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The Sound of Evolution
Ticagrelor
替格瑞洛
Mechanism of action:
Ticagrelor 是一種血小板 P2Y₁₂ 抑制劑（P2Y₁₂ receptor antagonist），屬於三唑嘧啶（triazolopyrimidine）的衍生物。在血小板活化過程中，二磷酸腺苷（ADP）會與血小板表面的 P2Y₁₂ 受體結合，促進 GPIIb/IIIa 受體的活化與構形改變（使其更易與纖維蛋白原結合），使血小板聚集形成血栓。Ticagrelor 能可逆性抑制血小板的 P2Y₁₂ 受體，抑制 ADP 所介導的訊號傳遞，預防血栓形成。
Reference(s):
1. Teng R et al. (2010). Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects. Drug Metab Dispos.
2. Angheloiu GO et al. (2017). Ticagrelor Removal From Human Blood. JACC Basic Transl Sci.
3. Dorsam RT et al. (2004). Central role of the P2Y12 receptor in platelet activation. J Clin Invest.
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