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Ticarcillin

替卡西林
Mechanism of action:
Ticarcillin 是一種 β-內醯胺抗生素(β-lactam antibiotic),屬於羧基青黴素類(carboxypenicillin)。Ticarcillin 的 β-內醯胺(β-lactam)環可與細菌的青黴素結合蛋白(penicillin-binding proteins,PBPs)結合,抑制其轉肽酶(transpeptidase)活性,使肽聚醣(peptidoglycan)鏈無法交聯,最後細胞壁結構脆弱,因滲透壓而讓細菌裂解死亡。
Reference(s):
Chambers HF et al. (1990). Binding affinity for penicillin-binding protein 2a correlates with in vivo activity of beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus. J Infect Dis.
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