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The Sound of Evolution
Tinzaparin
汀札肝素
Mechanism of action:
Tinzaparin 是一種低分子量肝素（low molecular weight heparin）。Tinzaparin 能與抗凝血酶 III（antithrombin III）結合，增強其對凝血因子 Xa（factor Xa）的抑制作用。最終減少纖維蛋白（fibrin）的生成，防止血栓形成。
Reference(s):
1. Friedel HA et al. (1994). Tinzaparin. A review of its pharmacology and clinical potential in the prevention and treatment of thromboembolic disorders. Drugs.
2. Simonneau G et al. (1997). A comparison of low-molecular-weight heparin with unfractionated heparin for acute pulmonary embolism. The THESEE Study Group. N Engl J Med.
3. Planes A et al. (1999). Prevention of deep vein thrombosis after hip replacement--comparison between two low-molecular heparins, tinzaparin and enoxaparin. Thromb Haemost.
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