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Tioconazole

噻康唑

Mechanism of action:

Tioconazole 是一種咪唑類（imidazole）衍生物。Tioconazole 能抑制黴菌的羊毛甾醇-14α-脫甲基酶（lanosterol 14α-demethylase，CYP51），該酵素負責將羊毛固醇（lanosterol）轉化為麥角固醇（ergosterol）。當此步驟被阻斷，黴菌的細胞膜結構會變得不完整，且羊毛固醇因為無法轉化而不斷堆積，引起毒性，最終讓真菌生長受抑或死亡。

​Reference(s):

1. Ballard SA et al. (1988). A comparative study of 1-substituted imidazole and 1,2,4-triazole antifungal compounds as inhibitors of testosterone hydroxylations catalysed by mouse hepatic microsomal cytochromes P-450. Biochem Pharmacol. 


2. Fliri AF et al. (2005). Biological spectra analysis: Linking biological activity profiles to molecular structure. Proc Natl Acad Sci USA.

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