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Tobramycin

妥布黴素

Mechanism of action:

Tobramycin 是一種胺基醣苷類抗生素（aminoglycoside antibiotic）。Tobramycin 能不可逆地結合於 30S 核糖體亞基的 16S rRNA 與 S12 蛋白，影響 mRNA 的正確解讀，導致錯誤胺基酸被摻入蛋白質，生成異常或無功能蛋白質。

​Reference(s):

1. Serio AW et al. (2018). Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation. EcoSal Plus. 


2. Bulitta JB et al. (2015). Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling. Antimicrob Agents Chemother.

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