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Troleandomycin

醋竹桃黴素
Mechanism of action:
Troleandomycin 是一種巨環內酯類抗生素(macrolide antibiotic),作用於細菌的 50S 核糖體亞基,與 23S rRNA 鄰近肽鏈出口通道的區域結合,阻止轉位(translocation)與肽鏈延長,使細菌的蛋白質合成無法進行,導致細菌生長停滯。
Reference(s):
Weinberger M et al. (1977). Inhibition of theophylline clearance by troleandomycin. J Allergy Clin Immunol.
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