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Tubocurarine

筒箭毒鹼

Mechanism of action:

Tubocurarine 是一種非去極化型神經肌肉阻斷劑（non-depolarizing neuromuscular blocking agent），屬於植物來源的雙季銨類生物鹼（bis-quaternary ammonium alkaloid）。Tubocurarine 會與運動終板上（motor end-plate）的菸鹼型乙醯膽鹼受體（nicotinic acetylcholine receptor）結合，阻止乙醯膽鹼（acetylcholine）與受體結合，導致鈉離子通道（sodium channel）不開啟，終板電位無法達到動作電位閾值，肌肉纖維因此無法收縮。

​Reference(s):

1. Bowman WC et al. (2006). Neuromuscular block. Br J Pharmacol. 


2. Singla D et al. (2010). BIAdb: a curated database of benzylisoquinoline alkaloids. BMC Pharmacol. 


3. Matteo RS et al. (1984). Distribution, elimination, and action of d-tubocurarine in neonates, infants, children, and adults. Anesth Analg.

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