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The Sound of Evolution
Umeclidinium
烏美溴銨
Mechanism of action:
Umeclidinium 是一種抗毒蕈鹼型乙醯膽鹼受體的支氣管擴張劑（muscarinic acetylcholine receptor antagonist），屬於季銨類（quaternary ammonium）化合物。Umeclidinium 能選擇性拮抗支氣管平滑肌上的毒蕈鹼型乙醯膽鹼受體（muscarinic acetylcholine receptor），特別是 M₃ 受體（Gq/11 蛋白偶聯受體），阻止乙醯膽鹼（acetylcholine）的作用，使細胞質鈣離子濃度下降，讓支氣管平滑肌放鬆。
Reference(s):
1. Feldman GJ et al. (2013). The combination of umeclidinium bromide and vilanterol in the management of chronic obstructive pulmonary disease: current evidence and future prospects. Ther Adv Respir Dis.
2. Decramer M et al. (2013). Bronchodilation of umeclidinium, a new long-acting muscarinic antagonist, in COPD patients. Respir Physiol Neurobiol.
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