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Urofollitropin
尿卵泡激素
Mechanism of action:
Urofollitropin 是一種人類尿源性濾泡刺激素(follicle-stimulating hormone)。Urofollitropin 與卵巢或睪丸上的促卵泡激素受體(follicle-stimulating hormone receptor)結合後,啟動 Gs 蛋白,刺激腺苷酸環化酶(adenylyl cyclase),使細胞內 cAMP 濃度上升,活化蛋白激酶 A(protein kinase A),進而調控多種與生殖細胞發育相關的基因轉錄,促進細胞分化與功能成熟。
Reference(s):
Goa KL et al. (1998). Follitropin alpha in infertility: a review. BioDrugs.
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