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Valdecoxib

伐地考昔

Mechanism of action:

Valdecoxib 是一種選擇性環氧化酶-2 抑制劑（selective COX-2 inhibitor）。Valdecoxib 主要抑制環氧化酶-2（cyclooxygenase-2，COX-2）將花生四烯酸（arachidonic acid）轉化為前列腺素（prostaglandin），降低與發炎、疼痛敏化與發燒反應相關的前列腺素訊號傳遞。

​Reference(s):

1. Talley JJ et al. (2000). 4-[5-Methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. J Med Chem. 


2. Jain KK et al. (2000). Evaluation of intravenous parecoxib for the relief of acute post-surgical pain. Expert Opin Investig Drugs. 


3. Yuan JJ et al. (2002). Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human. Drug Metab Dispos.

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