The Sound of Evolution
Vecuronium
維庫溴銨
Mechanism of action:
Vecuronium 是一種非去極化型神經肌肉阻斷劑（non-depolarizing neuromuscular blocking agent），屬於類固醇骨架衍生物（steroid-based compound）。Vecuronium 會與運動終板（motor end-plate）上的菸鹼型乙醯膽鹼受體（nicotinic acetylcholine receptor）結合，與乙醯膽鹼（acetylcholine）形成競爭性拮抗。當 vecuronium 佔據受體後，乙醯膽鹼無法引發鈉離子內流，神經肌肉的運動終板無法產生去極化電位，因而阻斷肌肉動作電位的產生。
Reference(s):
1. Jonsson Fagerlund M et al. (2009). Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology.
2. Liu M et al. (2008). Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg.
3. Paul M et al. (2002). Characterization of the interactions between volatile anesthetics and neuromuscular blockers at the muscle nicotinic acetylcholine receptor. Anesth Analg.