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Vidarabine

阿糖腺苷

Mechanism of action:

Vidarabine 是一種嘌呤核苷（purine nucleoside）類似物，屬於腺苷（adenosine）衍生物。Vidarabine 進入受病毒感染的細胞後，由宿主細胞的激酶磷酸化為 vidarabine triphosphate，能競爭性抑制病毒 DNA 聚合酶，使病毒的 DNA 無法複製；也能被錯誤嵌入病毒 DNA，導致病毒 DNA 結構異常。

​Reference(s):

1. Suzuki M et al. (2006). Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 


2. Sagar S et al. (2010). Antiviral lead compounds from marine sponges. Mar Drugs.

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