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The Sound of Evolution
Vilanterol
維蘭特羅
Mechanism of action:
Vilanterol 是一種選擇性 β₂-腎上腺素受體促效劑（long-acting β₂-adrenergic receptor agonist）。Vilanterol 會與支氣管平滑肌細胞膜上的 β₂-腎上腺素受體結合，活化腺苷酸環化酶（adenylyl cyclase），增加細胞內 cAMP 濃度，接著活化蛋白激酶 A（PKA），讓細胞質的 Ca²⁺ 濃度下降，促進平滑肌鬆弛。最終導致支氣管平滑肌鬆弛與支氣管擴張。
Reference(s):
1. Harrell AW et al. (2013). Metabolism and disposition of vilanterol, a long-acting beta(2)-adrenoceptor agonist for inhalation use in humans. Drug Metab Dispos.
2. Spyratos D et al. (2015). Umeclidinium bromide/vilanterol combination in the treatment of chronic obstructive pulmonary disease: a review. Ther Clin Risk Manag.
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