The Sound of Evolution
Vilazodone
維拉佐酮
Mechanism of action:
Vilazodone 是一種血清素再回收抑制劑兼部分促效劑（serotonin reuptake inhibitor and partial agonist）。Vilazodone 能抑制神經元的血清素轉運蛋白（serotonin transporter），使突觸間隙中的血清素（5-HT）濃度上升，增強血清素的作用。此外，vilazodone 同時對突觸前、後的 5-HT₁A 受體具有部分促效活性，在突觸前能減少過度的負回饋抑制；在突觸後，能減少焦慮與情緒調節。
Reference(s):
1. Cruz MP et al. (2012). Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T.
2. Chavan BB et al. (2017). Identification and characterization of vilazodone metabolites in rats and microsomes by ultrahigh-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry. Rapid Commun Mass Spectrom.
3. Wang SM et al. (2013). A review of current evidence for vilazodone in major depressive disorder. Int J Psychiatry Clin Pract.