The Sound of Evolution
Vortioxetine
伏硫西汀
Mechanism of action:
Vortioxetine 是一種多重血清素調節劑（serotonin modulator）。Vortioxetine 可抑制神經元的血清素轉運蛋白（serotonin transporter），使其無法回收，導致突觸間隙的血清素（5-HT）濃度上升，增強血清素的作用。Vortioxetine 亦直接作用於多個 5-HT 受體，可促效 5-HT₁A 受體；部分促效 5-HT₁B 受體；拮抗 5-HT₃ 和 5-HT₇ 受體，綜合調節憂鬱症的狀態。
Reference(s):
1. Bang-Andersen B et al. (2011). Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem.
2. Stenkrona P et al. (2013). 5-HTT and 5-HT(1A) receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects. Eur Neuropsychopharmacol.
3. Mork A et al. (2013). Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats. Pharmacol Biochem Behav.