The Sound of Evolution
Zopiclone
佐匹克隆
Mechanism of action:
Zopiclone 是一種環吡咯酮（cyclopyrrolone）衍生物，是 R+S 外消旋（racemate）混合物。Zopiclone 會與 GABA_A 受體上的 BZ₁ 位點結合，屬於正向變構調節（positive allosteric modulation），增強 GABA 的抑制性作用，增加氯離子通道（Cl⁻ channel）開啟頻率，促使氯離子流入神經元，造成神經元膜電位超極化（hyperpolarization），降低中樞神經興奮性。
Reference(s):
1. Liu HJ et al. (1985). Pharmacologic studies of the central action of zopiclone: effects on locomotor activity and brain monoamines in rats. Int J Clin Pharmacol Ther Toxicol.
2. Sato K et al. (1985). Pharmacologic studies of central actions of zopiclone: influence on brain monoamines in rats under stressful condition. Int J Clin Pharmacol Ther Toxicol.
3. Dundar Y et al. (2004). Comparative efficacy of newer hypnotic drugs for the short-term management of insomnia: a systematic review and meta-analysis. Hum Psychopharmacol.