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A Brief Analysis of Ebola Virus and the Human Immune System


Ebola virus under electron microscopy(圖片來源:Cynthia Goldsmith,CC0 1.0 公共領域)
Ebola virus under electron microscopy(圖片來源:Cynthia Goldsmith,CC0 1.0 公共領域)

In 1976, a terrifying infectious disease broke out in villages near the Ebola River in Zaire, now known as the Democratic Republic of the Congo. Individuals who became infected developed severe symptoms including systemic bleeding, fever, myocardial complications, and multiple organ failure. The first documented patient was a teacher named Mabalo Lokela. At the beginning of his illness, the disease was mistaken for malaria, and he was treated with injections of quinine. His condition, however, deteriorated rapidly. Bleeding soon appeared throughout his body, and he died shortly after infection. In the same year, a similar outbreak also occurred in Sudan. The causative agent was later identified as a virus and was named the Ebola virus after the river near where it was first detected, while the disease it causes became known as Ebola hemorrhagic fever.


Once a person becomes infected with the Ebola virus, the fatality rate may range from 40 percent to 90 percent, and in some outbreaks it approaches nearly 100 percent. More than thirty years later, in September 2007, another outbreak occurred in the Democratic Republic of the Congo. Subsequently, numerous cases emerged in Guinea in West Africa in January 2014. That epidemic continued until early 2016 before finally subsiding. During that time, cases were no longer limited to African countries. In October 2014, individuals who tested positive for the virus were reported in the United States, Germany, Spain, and other countries. Additional outbreaks occurred between 2018 and 2021. The most recent outbreak took place in Uganda in East Africa in 2022, involving the Sudan strain of the virus and resulting in 77 deaths.

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